Mu-opioid receptors in the caudomedial NTS are critical for respiratory responses to stimulation of bronchopulmonary C-fibers and carotid body in conscious rats

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• 作者：Jianguo Zhuang ; Xiuping Gao ; Franklin Gao ; Fadi Xu ; MD ; ^fxu@lrri.org
• 关键词：Opioid ; Anesthesia ; Respiration ; Chemoreception
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：235
• 期：Complete
• 页码：71-78
• 全文大小：2263 K
• 卷排序：235

文摘

The cmNTS presents the highest MORs in the caudal medulla. Activation of cmNTS MORs blocks or almost eliminates the PCF-mediated apnea and HVR in the intact rats with HCVR inhibited in the carotid body ablated rats. Our data imply a presence of MORs in the synapse of the 2nd-order neurons receiving inputs from PCFs and the carotid and NTS chemosensitive neurons.