Abietane Diterpenoids from Salvia pachyphylla and S. clevelandii with Cytotoxic Activity against Human Cancer Cell Lines

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• 作者：Iv&aacute ; n C. Guerrero ; Lucí ; a S. André ; s ; Leticia G. Leó ; n ; Rubé ; n P. Machí ; n ; José ; M. Padró ; n ; Javier G. Luis ; José ; Delgadillo
• 刊名：Journal of Natural Products
• 出版年：2006
• 出版时间：December 2006
• 年：2006
• 卷：69
• 期：12
• 页码：1803 - 1805
• 全文大小：44K
• 年卷期：v.69,no.12(December 2006)
• ISSN：1520-6025

文摘

A phytochemical study has been carried out on the aerial parts of Salvia pachyphylla and S. clevelandii. From S.pachyphylla, the known diterpenes carnosol (2), rosmanol, 20-deoxocarnosol (3), carnosic acid, isorosmanol (4),7-methoxyrosmanol, 5,6-didehydro-O-methylsugiol (5), 8ges/gifchars/beta2.gif" BORDER=0 ALIGN="middle">-hydroxy-9(11),13-abietadien-12-one (6), 11,12-dioxoabieta-8,13-diene, and 11,12-dihydroxy-20-norabieta-5(10),8,11,13-tetraen-1-one were isolated, together with the new diterpenepachyphyllone (1). From S. clevelandii, the known diterpenes rosmadial (7), 16-hydroxycarnosol (8), abieta-8,11,13-triene, and taxodone were obtained, together with carnosol (2), rosmanol, and carnosic acid. The structure of the newcompound (1) was identified on the basis of spectroscopic data analysis. Several of these compounds (1-8) were evaluatedagainst a small panel of human cancer cell lines.