Commercially available amphiphilic cyclodextrins, namely per-6-
O-(
tert-butyldimethylsilyl)
,
and
cyclodextrins (TBDMS-
-, -
-, and -
-CDs) were subjected to a thorough Langmuir monolayercharacterization, using both traditional methods of surface manometry (
/A isotherms, stability experiments)and modern mic
rometer/nanometer resolution (BAM, AFM) surface techniques. It has been found thatinconsistent behavior regarding the isotherms reproducibility obtained upon compression of TBDMS-
-CDs is due to the aggregation of the investigated molecules in chloroform and hexane, while goodreproducibility ensured a mixed spreading solvent system of hexane/
isopropanol 7:3 (v/v). Although the stabilityof films dropped f
rom chloroform and hexane/
isopropanol solvents below the equilibrium surface pressure(ESP) was comparable, pronounced differences were observed at pressures above ESP. The investigatedTBDMS-CDs were successfully transferred onto cadmium stearate covered mica substrates. AFM imagesconfirmed the presence of discontinuous multilayered films (10 nm heights) spread f
rom chloroform versusmonomolecular dispersion achieved in hexane/
isopropanol.