Nanoroughened Surfaces for Efficient Capture of Circulating Tumor Cells without Using Capture Antibodies

详细信息    查看全文

• 作者：Weiqiang Chen ; Shinuo Weng ; Feng Zhang ; Steven Allen ; Xiang Li ; Liwei Bao ; Raymond H. W. Lam ; Jill A. Macoska ; Sofia D. Merajver ; Jianping Fu
• 刊名：ACS Nano
• 出版年：2013
• 出版时间：January 22, 2013
• 年：2013
• 卷：7
• 期：1
• 页码：566-575
• 全文大小：718K
• 年卷期：v.7,no.1(January 22, 2013)
• ISSN：1936-086X

文摘

Circulating tumor cells (CTCs) detached from both primary and metastatic lesions represent a potential alternative to invasive biopsies as a source of tumor tissue for the detection, characterization and monitoring of cancers. Here we report a simple yet effective strategy for capturing CTCs without using capture antibodies. Our method uniquely utilized the differential adhesion preference of cancer cells to nanorough surfaces when compared to normal blood cells and thus did not depend on their physical size or surface protein expression, a significant advantage as compared to other existing CTC capture techniques.

Keywords:

cancer; circulating tumor cell; nanotopography; biomaterials; microfabrication