Aminorifamycins and Sporalactams Produced in Culture by a Micromonospora sp. Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics

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• 作者：David E. Williams ; Doralyn S. Dalisay ; Jessie Chen ; Elena A. Polishchuck ; Brian O. Patrick ; Gagandeep Narula ; Mary Ko ; Yossef Av-GayHaoxin Li ; Nathan Magarvey ; Raymond J. Andersen
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：19
• 期：4
• 页码：766-769
• 全文大小：309K
• ISSN：1523-7052

文摘

The new ansa macrolide antibiotics 1 to 4 have been isolated from cultures of a Micromonospora sp. obtained from a marine sediment. Rifamycins 1 and 2 are the first natural ansa macrolides to have a 3-amino substituent. Sporalactams A (3) and B (4) are comprised of a heterocylic core 5 and a 14-membered ansa bridge that are both unprecedented. Sporalactam B (4) shows selective and potent inhibition of Mycobacterium tuberculosis.