Pierisketolide A and Pierisketones B and C, Three Diterpenes with an Unusual Carbon Skeleton from the Roots of Pieris formosa

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• 作者：Chang-Shan Niu ; Yong Li ; Yun-Bao Liu ; Shuang-Gang Ma ; Fei Liu ; Li Li ; Song Xu ; Xiao-Jing Wang ; Ru-Bing Wang ; Jing Qu ; Shi-Shan Yu
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：19
• 期：4
• 页码：906-909
• 全文大小：323K
• ISSN：1523-7052

文摘

Pierisketolide A (1) and pierisketones B and C (2 and 3), three diterpenes with an unusual A-homo-B-nor-ent-kaurane carbon skeleton, were isolated from the roots of Pieris formosa. Their structures were characterized by a series of spectroscopic methods, X-ray diffraction, and electronic circular dichroism (ECD). Pierisketolide A (1) exhibited an analgesic effect with a 45% writhe inhibition rate at a dose of 10.0 mg/kg. The plausible biosynthetic pathways of 1–3 are proposed.