Double Dearomatization of Bis(diphenylphosphinamides) through Anionic Cyclization. A Facile Route of Accessing Multifunctional Systems with Antitumor Properties 详细信息    查看全文 作者：Gloria Ruiz-G&oacute ; mez ; Marí ; a José ; Iglesias ; Manuel Serrano-Ruiz ; Santiago Garcí ; a-Granda ; André ; s Francesch ; Fernando L&oacute ; pez-Ortiz ; Carmen Cuevas 刊名：Journal of Organic Chemistry 出版年：2007 出版时间：May 11, 2007 年：2007 卷：72 期：10 页码：3790 - 3799 全文大小：229K 年卷期：v.72,no.10(May 11, 2007) ISSN：1520-6904 文摘 LE>

ls/joceah/72/i10/figures/jo070276qn00002.gif" ALIGN="left" HSPACE=5>

The sequential one-pot double dearomatization of bis(N-benzyl-P,P-diphenylphosphinamides) via anioniccyclization is described for the first time. Protonation and alkylation of the dearomatized dianions providebis(tetrahydro-2,1-benzazaphospholes) in good yield and with very high regio- and stereocontrol. Acid-catalyzed methanolysis of the bisheterocycles affords bis(methyl -aminophosphinates) stereospecifically.The doubly phosphorylated systems proved to be active against a series of cancer cell lines.