Pyrazolofluostatins A–C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160

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• 作者：Wenjun Zhang ; Chunfang Yang ; Chunshuai Huang ; Liping Zhang ; Haibo ZhangQingbo Zhang ; Cheng-shan Yuan ; Yiguang Zhu ; Changsheng Zhang
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：19
• 期：3
• 页码：592-595
• 全文大小：345K
• ISSN：1523-7052

文摘

Pyrazolofluostatins A–C (1–3), three new benzo[a]fluorenes with an unprecedented carbon skeleton, were obtained from the South China Sea-derived Micromonospora rosaria SCSIO N160. Their structures were elucidated by extensive spectroscopic analyses. The structure of pyrazolofluostatin A (1) was confirmed by X-ray crystallographic analysis. Notably, 1–3 possessed a benzo[cd]indeno[2,1-f]indazol skeleton with a pyrazole-fused 6/5/6/6/5 pentacyclic ring system. Pyrazolofluostatin A (1) showed moderate antioxidation activity (EC₅₀ 48.6 μM).