Substituted 2-Phenylimidazopyridines: A New Class of Drug Leads for Human African Trypanosomiasis

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• 作者：Hari Babu Tatipaka ; J. Robert Gillespie ; Arnab K. Chatterjee ; Neil R. Norcross ; Matthew A. Hulverson ; Ranae M. Ranade ; Pendem Nagendar ; Sharon A. Creason ; Joshua McQueen ; Nicole A. Duster ; Advait Nagle ; Frantisek Supek ; Valentina Molteni ; Tanja Wenzler ; Reto Brun ; Richard Glynne ; Frederick S. Buckner ; Michael H. Gelb
• 刊名：Journal of Medicinal Chemistry
• 出版年：2014
• 出版时间：February 13, 2014
• 年：2014
• 卷：57
• 期：3
• 页码：828-835
• 全文大小：288K
• ISSN：1520-4804

文摘

A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of human African trypanosomiasis, led to the identification of substituted 2-(3-aminophenyl)oxazolopyridines as a starting point for hit-to-lead medicinal chemistry. A total of 110 analogues were prepared, which led to the identification of 64, a substituted 2-(3-aminophenyl)imidazopyridine. This compound showed antiparasitic activity in vitro with an EC₅₀ of 2 nM and displayed reasonable druglike properties when tested in a number of in vitro assays. The compound was orally bioavailable and displayed good plasma and brain exposure in mice. Compound 64 cured mice infected with Trypanosoma brucei when dosed orally down to 2.5 mg/kg. Given its potent antiparasitic properties and its ease of synthesis, compound 64 represents a new lead for the development of drugs to treat human African trypanosomiasis.