Cobalt-Catalyzed Annulation of Amides with Isocyanides via C(sp2)–H Activation

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• 作者：Zheng-Yang Gu ; Cheng-Guo Liu ; Shun-Yi WangShun-Jun Ji
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：82
• 期：4
• 页码：2223-2230
• 全文大小：519K
• ISSN：1520-6904

文摘

A cobalt-catalyzed [4 + 1] cycloaddition of easily accessible amides with isocyanides for the efficient synthesis of 3-iminoisoindolinone derivatives in high yield under mild conditions via intramolecular C(sp²)–H activation and isocyanide insertion is reported. The annulation was found to be applicable to a broad range of substrates, including arylamides, heteroarylamides, and acrylamide derivatives. Strongly coordinating N-heterocyclic directing groups such as pyridine, pyrimidine, and even pyrazole were fully tolerated in this cobalt-catalyzed C–H activation reaction.