Ultrasound-Induced Reactive Oxygen Species Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome

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• 作者：Wei-Peng Li ; Chia-Hao Su ; Yi-Ching Chang ; Yu-Jiung Lin ; Chen-Sheng Yeh
• 刊名：ACS Nano
• 出版年：2016
• 出版时间：February 23, 2016
• 年：2016
• 卷：10
• 期：2
• 页码：2017-2027
• 全文大小：541K
• ISSN：1936-086X

文摘

Ultrasound techniques have been extensively employed for diagnostic purposes. Because of its features of low cost, easy access, and noninvasive real-time imaging, toward clinical practice it is highly anticipated to simply use diagnostic ultrasound to concurrently perform imaging and therapy. We report a H<sub>2sub>O<sub>2sub>-filled polymersome to display echogenic reflectivity and reactive oxygen species-mediated cancer therapy simply triggered by the microultrasound diagnostic system accompanied by MR imaging. Instead of filling common perfluorocarbons, the encapsulation of H<sub>2sub>O<sub>2sub> in H<sub>2sub>O<sub>2sub>/Fe<sub>3sub>O<sub>4sub>–PLGA polymersome provides O<sub>2sub> as the echogenic source and <sup>•sup>OH as the therapeutic element. On exposure to ultrasound, the polymersome can be easily disrupted to yield <sup>•sup>OH through the Fenton reaction by reaction of H<sub>2sub>O<sub>2sub> and Fe<sub>3sub>O<sub>4sub>. We showed that malignant tumors can be completely removed in a nonthermal process.