Enantioselective Synthesis of [6]Carbohelicenes

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• 作者：Elisa González-Fernández ; Leo D. M. Nicholls ; Lukas D. Schaaf ; Christophe Farès ; Christian W. Lehmann ; Manuel Alcarazo
• 刊名：Journal of the American Chemical Society
• 出版年：2017
• 出版时间：February 1, 2017
• 年：2017
• 卷：139
• 期：4
• 页码：1428-1431
• 全文大小：412K
• ISSN：1520-5126

文摘

The use of α-cationic phosphonites derived from TADDOL as ancillary ligands has allowed a highly regio- and enantioselective synthesis of substituted [6]carbohelicenes by sequential Au-catalyzed intramolecular hydroarylation of diynes. Key for these results is the modular structure of these new ligands, and the enhanced reactivity that they impart to Au(I)-centers after coordination.