Impact of Mixed 尾-Cyclodextrin Ratios on Pluronic Rotaxanation Efficiency and Product Solubility

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• 作者：Yawo A. Mondjinou ; Seok-Hee Hyun ; Manxi Xiong ; Christopher J. Collins ; Pooi Ling Thong ; David H. Thompson
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：November 4, 2015
• 年：2015
• 卷：7
• 期：43
• 页码：23831-23836
• 全文大小：336K
• ISSN：1944-8252

文摘

Water-soluble polyrotaxanes have been prepared under heterogeneous conditions from mixtures of 尾-cyclodextrin (尾-CD), 2-hydroxypropyl-尾-cyclodextrin (HP-尾-CD), methyl-尾-cyclodextrin, or 6-monoazido-尾-cyclodextrin with 4-sulfobutyl ether-尾-cyclodextrin (SBE-尾-CD) and Pluronic L81 copolymer modified with cholesterol end caps. Threading reactions gave polyrotaxane products in modest chemical yield that were reflective of the 尾-CD feed ratios in the reaction. Polyrotaxanes containing mixtures of HP-尾-CD and SBE-尾-CD were screened and found to be biologically active in an in vitro model of Niemann-Pick Type C disease where they mobilize aberrantly stored cholesterol similarly to monomeric cyclodextrin controls.