Short and Scalable Total Synthesis of Myrioneuron Alkaloids (±)-α,β-Myrifabral A and B

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• 作者：Dengpeng Song ; Zhengshen Wang ; Ruoming Mei ; Weiwei Zhang ; Donghui Ma ; Dengyu Xu ; Xingang Xie ; Xuegong She
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：February 19, 2016
• 年：2016
• 卷：18
• 期：4
• 页码：669-671
• 全文大小：268K
• ISSN：1523-7052

文摘

The first total synthesis of the Myrioneuron alkaloids (±)-α,β-myrifabral A and B has been accomplished in only four steps from conveniently available starting materials. This short synthesis relied on the use of a key tandem Mannich/amidation reaction to rapidly construct the core framework and two carbon stereocenters. The synthetic route allows for large scale preparation of these promising natural products against the hepatitis C virus (HCV).