Silver-Catalyzed Oxidative Cyclization of Propargylamide-Substituted Indoles: Synthesis of Phosphorated Indoloazepinones Derivatives

详细信息    查看全文

• 作者：Hui-Liang Hua ; Bo-Sheng Zhang ; Yu-Tao He ; Yi-Feng Qiu ; Xin-Xing Wu ; Peng-Fei Xu ; Yong-Min Liang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：January 15, 2016
• 年：2016
• 卷：18
• 期：2
• 页码：216-219
• 全文大小：426K
• ISSN：1523-7052

文摘

A silver-catalyzed oxidative cyclization of 2- or 3-propargylamide-substituted indoles to synthesize phosphorated indoloazepinone derivatives is described. This reaction displays a difunctionalizalion of alkynes with diphenylphosphine oxides to construct a seven-membered ring through a radical cyclization process. The indoloazepinones derivatives are common structural motifs found in many natural products and pharmaceuticals.