Spirocyclic Lignans from Guaiacum (Zygophyllaceae) Induce Apoptosis in Human Breast Cancer Cell Lines

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• 作者：Kathryn J. Chavez ; Xiaohong Feng ; James A. Flanders ; Eloy Rodriguez ; Frank C. Schroeder
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：May 27, 2011
• 年：2011
• 卷：74
• 期：5
• 页码：1293-1297
• 全文大小：833K
• 年卷期：v.74,no.5(May 27, 2011)
• ISSN：1520-6025

文摘

We investigated the composition of extracts derived from Guaiacum spp. (Zygophyllaceae), a group of neotropical tree species with varied uses in Central and South American traditional medicine. Activity-guided fractionation of Guaiacum heartwood extracts led to the identification of four new spirocyclic lignans, named ramonanins A鈭扗 (<b>1b>鈭?b>4b>). The ramonanins exhibit cytotoxic activity against human breast cancer cell lines with an ICb>50b> value of 18 渭M and induce cell death via apoptotic mechanisms. The ramonanins are derived from four units of coniferyl alcohol and feature an unusual spirocyclic ring system.