β-Cyclodextrin-Bearing Gold Glyconanoparticles for the Development of Site Specific Drug Delivery Systems

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• 作者：Ahmet Ayka? ; Manuel C. Martos-Maldonado ; Juan M. Casas-Solvas ; Indalecio Quesada-Soriano ; Federico García-Maroto ; Luís García-Fuentes ; Antonio Vargas-Berenguel
• 刊名：Langmuir
• 出版年：2014
• 出版时间：January 14, 2014
• 年：2014
• 卷：30
• 期：1
• 页码：234-242
• 全文大小：476K
• ISSN：1520-5827

文摘

Three novel gold nanoparticles containing multiple long, flexible linkers decorated with lactose, 尾-cyclodextrin, and both simultaneously have been prepared. The interaction of such nanoparticles with 尾-d-galactose-recognizing lectins peanut agglutinin (PNA) and human galectin-3 (Gal-3) was demonstrated by UV鈥搗is studies. Gal-3 is well-known to be overexpressed in several human tumors and can act as a biorecognizable target. This technique also allowed us to estimate their loading capability toward the anticancer drug methotrexate (MTX). Both results make these glyconanoparticles potential site-specific delivery systems for anticancer drugs.