First Crystal Structure for a Gold Carbene–Protein Adduct

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• 作者：Giarita Ferraro ; Chiara Gabbiani ; Antonello Merlino
• 刊名：Bioconjugate Chemistry
• 出版年：2016
• 出版时间：July 20, 2016
• 年：2016
• 卷：27
• 期：7
• 页码：1584-1587
• 全文大小：311K
• 年卷期：0
• ISSN：1520-4812

文摘

The X-ray structure of the adduct formed in the reaction between the gold N-heterocyclic carbene compound Au(NHC)Cl (with NHC = 1-butyl-3-methyl-imidazole-2-ylidene) and the model protein thaumatin is reported here. The structure reveals binding of Au(NHC)⁺ fragments to distinct protein sites. Notably, binding of the gold compound occurs at lysine side chains and at the N-terminal tail; the metal binds the protein after releasing Cl^– ligand, but retaining NHC fragment.