Radiopaque Organic-Inorganic Hybrids Based on Poly(D,L-lactide)

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• 作者：Laura Mazzocchetti ; Sergio Sandri ; Mariastella Scandola ; Anna Bergia ; Giampaolo Zuccheri
• 刊名：Biomacromolecules
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：8
• 期：2
• 页码：672 - 678
• 全文大小：517K
• 年卷期：v.8,no.2(February 2007)
• ISSN：1526-4602

文摘

Hybrid organic-inorganic nanocomposites were prepared starting from ,-triethoxysilane-terminated poly(D,L-lactic acid) (PDLLA) to be used as potential radiopaque biocompatible coatings for medical devices. The synthesisof the organic phase precursors of given chain length was achieved via anionic polymerization of D,L-lactideusing a bifunctional initiator and subsequent triethoxysilane functionalization of the end groups. PDLLA-basedceramers (ceramic polymers) were then synthesized by the sol-gel process at room temperature (rt) in the presenceof different amounts of tetraethoxysilane. The rt-synthesized hybrids were then cured (at 80 or 130 C), and theirthermal and viscoelastic properties were investigated. All obtained hybrids were optically transparent, due to thenanometric dimension of the silica particles, and yielded clearly contrasted radiographic images.