Boronic Acid-Functionalized Particles with Flexible Three-Dimensional Polymer Branch for Highly Specific Recognition of Glycoproteins

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• 作者：Jianxi Liu ; Kaiguang Yang ; Wenya Shao ; Yanyan Qu ; Senwu Li ; Qi Wu ; Lihua Zhang ; Yukui Zhang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：April 20, 2016
• 年：2016
• 卷：8
• 期：15
• 页码：9552-9556
• 全文大小：267K
• 年卷期：0
• ISSN：1944-8252

文摘

A novel organic–inorganic hybrid particle with high hydrophilicity three-dimensional boronic acid functional polymer branches was facilely synthesized through thiol–ene surface-initiated click reaction, by which the target glycoprotein could be captured selectively in the 5000-fold disrupting protein. This highest selectivity ever reported demonstrated that this boronic acid functionalized particle exhibited great potential in the recognition of cis-diol-containing biomolecules, including the glycoproteins.