IgG Antibody Response Elicited by a Fully Synthetic Two-Component Carbohydrate-Based Cancer Vaccine Candidate with α-Galactosylceramide as Built-in Adjuvant

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• 作者：Xu-Guang Yin ; Xiang-Zhao Chen ; Wen-Mei Sun ; Xiao-Shan Geng ; Xiao-Kang Zhang ; Jian Wang ; Pan-Pan Ji ; Zhong-Yin Zhou ; Dong Jae Baek ; Guang-Fu YangZheng Liu ; Jun Guo
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：19
• 期：3
• 页码：456-459
• 全文大小：420K
• ISSN：1523-7052

文摘

A fully synthetic self-adjuvanting cancer vaccine candidate was constructed through covalent conjugation of invariant natural killer T (iNKT) cell ligand α-galactosylceramide (αGalCer) with sialyl Tn (STn), a representative tumor-associated carbohydrate antigen (TACA). This two-component vaccine STn-αGalCer is devoid of antigenic peptide, featuring the well-defined structure with high simplicity. STn-αGalCer showed remarkable efficacy in inducing antibody class switching from IgM to STn-specific IgG. Subtypes of IgG antibody were primarily IgG1 and IgG3.