Palladium-Catalyzed Cyclization-Heck Reaction of Allenamides: An Approach to 3-Methylene-5-phenyl-1,2,3,4-tetrahydropyridine Derivatives

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• 作者：Fachao Yan ; Hanbing Liang ; Jian Song ; Jie Cui ; Qing Liu ; Sheng Liu ; Ping Wang ; Yunhui Dong ; Hui Liu
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：19
• 期：1
• 页码：86-89
• 全文大小：372K
• ISSN：1523-7052

文摘

An efficient one-pot construction of functionalized 3-methylene-5-phenyl-1,2,3,4-tetrahydropyridine derivatives via palladium-catalyzed cyclization-Heck reaction of allenamides has been described. The 3-methylene-5-phenyl-1,2,3,4-tetrahydropyridine derivatives feature a nonconjugated diene, including one endo-enamine and one exocyclic double bond, which could be used for further transformation. Both aryl and vinyl halides performed very well under the standard conditions, delivering the corresponding products efficiently.