Novel l-Xylose Derivatives as Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes

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• 作者：Nicole C. Goodwin ; Ross Mabon ; Bryce A. Harrison ; Melanie K. Shadoan ; Zheng Y. Almstead ; Yiling Xie ; Jason Healy ; Lindsey M. Buhring ; Christopher M. DaCosta ; Jennifer Bardenhagen ; Faika Mseeh ; Qingyun
• 刊名：Journal of Medicinal Chemistry
• 出版年：2009
• 出版时间：October 22, 2009
• 年：2009
• 卷：52
• 期：20
• 页码：6201-6204
• 全文大小：728K
• 年卷期：v.52,no.20(October 22, 2009)
• ISSN：1520-4804

文摘

The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.