Oxysterol-Induced Rearrangement of the Liquid-Ordered Phase: A Possible Link to Alzheimer’s Disease?

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• 作者：Hideyuki Mitomo ; Wen-Hua Chen ; Steven L. Regen
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：September 2, 2009
• 年：2009
• 卷：131
• 期：34
• 页码：12354-12357
• 全文大小：219K
• 年卷期：v.131,no.34(September 2, 2009)
• ISSN：1520-5126

文摘

Nearest-neighbor recognition measurements have been made for an exchangeable phospholipid (A) interacting with an exchangeable form of cholesterol (B) in host membranes derived from 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine and varying concentrations of cholesterol, 7β-hydroxycholesterol (7β-OH), and 25-hydroxycholesterol (25-OH). Whereas partial replacement of cholesterol with 7β-OH strengthens the association between A and B, a similar substitution with 25-OH weakens this association. A model that accounts for this dichotomy, and the possible relevance of these findings to the cytotoxicity of 7β-OH and to Alzheimer’s disease are briefly discussed.