Acantholactam and Pre-neo-kauluamine, Manzamine-Related Alkaloids from the Indonesian Marine Sponge Acanthostrongylophora ingens

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• 作者：Ahmed H. El-Desoky ; Hikaru Kato ; Keisuke Eguchi ; Tetsuro Kawabata ; Yukio Fujiwara ; Fitje Losung ; Remy E. P. Mangindaan ; Nicole J. de Voogd ; Motohiro Takeya ; Hideyoshi Yokosawa ; Sachiko Tsukamoto
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：June 27, 2014
• 年：2014
• 卷：77
• 期：6
• 页码：1536-1540
• 全文大小：286K
• ISSN：1520-6025

文摘

Two new manzamine alkaloids, acantholactam (3) and pre-neo-kauluamine (4), were isolated from the marine sponge Acanthostrongylophora ingens along with manzamine A (1) and neo-kauluamine (2). Acantholactam contains a 纬-lactam ring N-substituted with a (Z)-2-hexenoic acid moiety and is proposed to be biosynthetically derived from manzamine A by oxidative cleavage of the eight-membered ring. Compound 4 was converted to the dimer 2 during storage, suggesting nonenzymatic dimer formation. Among the four isolated compounds, 1, 2, and 4 showed proteasome inhibitory activity.