Enantioselective Cyclization of 4-Alkenoic Acids via an Oxidative Allylic C鈥揌 Esterification

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• 作者：Kazuhiro Takenaka ; Mitsutoshi Akita ; Yugo Tanigaki ; Shinobu Takizawa ; Hiroaki Sasai
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：July 1, 2011
• 年：2011
• 卷：13
• 期：13
• 页码：3506-3509
• 全文大小：806K
• 年卷期：v.13,no.13(July 1, 2011)
• ISSN：1523-7052

文摘

An enantioselective intramolecular oxidative cyclization of 4-alkenoic acids was developed. The reaction proceeded via a 蟺-allyl Pd intermediate generated by an allylic C鈥揌 activation to give 纬-lactone derivatives with moderate to good enantioselectivity. Spiro bis(isoxazoline) ligand, SPRIX, was indispensable for this asymmetric transformation.