Facile Regio- and Stereoselective Metal-Free Synthesis of All-Carbon Tetrasubstituted Alkenes Bearing a C(sp3)鈥揊 Unit via Dehydroxyfluorination of Morita鈥揃aylis鈥揌illman (MBH) Adducts

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• 作者：Shinobu Takizawa ; Fernando Arteaga Arteaga ; Kenta Kishi ; Shuichi Hirata ; Hiroaki Sasai
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：August 15, 2014
• 年：2014
• 卷：16
• 期：16
• 页码：4162-4165
• 全文大小：301K
• ISSN：1523-7052

文摘

Highly E-selective all-carbon tetrasubstituted alkenes with a C(sp³)鈥揊 unit have been synthesized through a dehydroxyfluorination of Morita鈥揃aylis鈥揌illman (MBH) adducts which can be readily prepared from 伪,尾-unsaturated carbonyl compounds and 伪-keto esters. A variety of subsequent transformations afforded monofluoromethyl substituted heterocycles in high yields.