Ultrasensitive Profiling of Metabolites Using Tyramine-Functionalized Graphene Quantum Dots

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• 作者：Nan Li ; Aung Than ; Xuewan Wang ; Shaohai Xu ; Lei Sun ; Hongwei Duan ; Chenjie Xu ; Peng Chen
• 刊名：ACS Nano
• 出版年：2016
• 出版时间：March 22, 2016
• 年：2016
• 卷：10
• 期：3
• 页码：3622-3629
• 全文大小：568K
• ISSN：1936-086X

文摘

Graphene quantum dots (GQDs) are emerging fluorescence reporters attractive for optical sensing, owing to their high photostability, highly tunable photoluminescence, molecular size, atomically thin structure, biocompatibility, and ease of functionalization. Herein, we present a fluorometric sensing platform based on tyramine-functionalized GQDs, which is able to detect a spectrum of metabolites with high sensitivity and specificity. Furthermore, multiparametric blood analysis (glucose, cholesterol, l-lactate, and xanthine) is demonstrated. This convenient metabolite profiling technique could be instrumental for diagnosis, study, and management of metabolic disorders and associated diseases, such as diabetes, obesity, lactic acidosis, gout, and hypertension.