Inhibition of Pseudomonas aeruginosa Biofilm Formation with Bromoageliferin Analogues

详细信息    查看全文

• 作者：Robert W. Huigens III ; Justin J. Richards ; Gina Parise ; T. Eric Ballard ; Wei Zeng ; Rajendar Deora ; Christian Melander
• 刊名：Journal of the American Chemical Society
• 出版年：2007
• 出版时间：June 6, 2007
• 年：2007
• 卷：129
• 期：22
• 页码：6966 - 6967
• 全文大小：69K
• 年卷期：v.129,no.22(June 6, 2007)
• ISSN：1520-5126

文摘

Two analogues of the marine natural product bromoageliferin have been synthesized and subsequently assayed for the ability to inhibit the formation of Pseudomonas aeruginosa biofilms. Both compounds inhibited the ability of Pseudomonas aeruginosa strains PAO1 and PA14 to form biofilms; however, they displayed differential toxicity to planktonic bacteria. The cis analogue, CAGE, was found to possess greater toxicity than the trans analogue, TAGE. These compounds have no structural homology to any known inhibitors of Pseudomonas aeruginosa biofilms.