General Synthesis of Sugar-Derived Azepane Nitrones: Precursors of Azepane Iminosugars

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• 作者：Wen-Bo Zhao ; Shinpei Nakagawa ; Atsushi Kato ; Isao Adachi ; Yue-Mei Jia ; Xiang-Guo Hu ; George W. J. Fleet ; Francis X. Wilson ; Graeme Horne ; Akihide Yoshihara ; Ken Izumori ; Chu-Yi Yu
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：April 5, 2013
• 年：2013
• 卷：78
• 期：7
• 页码：3208-3221
• 全文大小：598K
• 年卷期：v.78,no.7(April 5, 2013)
• ISSN：1520-6904

文摘

A general and efficient method has been developed for the synthesis of sugar-derived azepane nitrones starting from aldohexoses, with an intramolecular condensation of aldehyde and hydroxylamine as the key step. Through this strategy, each aldohexose produced a pair of azepane nitrones, which are precursors of various azepane iminosugars.