Iridium-Catalyzed Asymmetric Hydrogenation of Ketones with Accessible and Modular Ferrocene-Based Amino-phosphine Acid (f-Ampha) Ligands

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• 作者：Jianfei Yu ; Jiao Long ; Yuhong Yang ; Weilong Wu ; Peng Xue ; Lung Wa ChungXiu-Qin Dong ; Xumu Zhang
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：19
• 期：3
• 页码：690-693
• 全文大小：410K
• ISSN：1523-7052

文摘

A series of tridentate ferrocene-based amino-phosphine acid (f-Ampha) ligands have been successfully developed. The f-Ampha ligands are extremely air stable and exhibited excellent performance in the Ir-catalyzed asymmetric hydrogenation of ketones (full conversions, up to >99% ee, and 500 000 TON). DFT calculations were performed to elucidate the reaction mechanism and the importance of the −COOH group. Control experiments also revealed that the −COOH group played a key role in this reaction.