Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity

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• 作者：Jeong-Tae Yeon ; Hiyoung Kim ; Kwang-Jin Kim ; Jihye Lee ; Dong Hwan Won ; Sang-Jip Nam ; Seong Hwan Kim ; Heonjoong Kang ; Young-Jin Son
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：July 22, 2016
• 年：2016
• 卷：79
• 期：7
• 页码：1730-1736
• 全文大小：510K
• 年卷期：0
• ISSN：1520-6025

文摘

A new inhibitor, acredinone C (1), of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation was isolated from the culture broth of the fungus Acremonium sp. (F9A015) along with acredinones A (2) and B (3). The structure of acredinone C (1), which incorporates benzophenone and xanthone moieties, was established by the analyses of combined spectroscopic data including 1D and 2D NMR and MS. All of the acredinones studied efficiently inhibited the RANKL-induced formation of TRAP⁺-MNCs in a dose-dependent manner without any cytotoxicity up to 10 μM. Acredinone A showed dual activity in both osteoclast and osteoblast differentiation in vitro and good efficacy in an animal disease model of bone formation.