Hydrogen Bond-Assisted 6蟺-Azaelectrocyclization of Penta-2,4-dienamides: Synthesis of Dihydropyridin-2(3H)-ones

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• 作者：Xu Liu ; Ning Zhang ; Jiming Yang ; Yongjiu Liang ; Rui Zhang ; Dewen Dong
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：April 5, 2013
• 年：2013
• 卷：78
• 期：7
• 页码：3323-3328
• 全文大小：272K
• 年卷期：v.78,no.7(April 5, 2013)
• ISSN：1520-6904

文摘

A facile and efficient synthesis of substituted dihydropyridin-2(3H)-ones is developed from penta-2,4-dienamides, in which an intramolecular C鈥揘 bond was formed through thermal 6蟺-azaelectrocyclization. The intramolecular hydrogen bonding-assisted cyclization reaction opens access to a variety of dihydropyridin-2(3H)-ones.