Unique Multifunctional Thermally-Induced Shape Memory Poly(p-dioxanone)鈥揚oly(tetramethylene oxide)glycol Multiblock Copolymers Based on the Synergistic Effect of Two Segments

详细信息    查看全文

• 作者：Jingjing Zhang ; Gang Wu ; Caili Huang ; Ying Niu ; Chao Chen ; Zhongtao Chen ; Keke Yang ; Yuzhong Wang
• 刊名：The Journal of Physical Chemistry C
• 出版年：2012
• 出版时间：March 8, 2012
• 年：2012
• 卷：116
• 期：9
• 页码：5835-5845
• 全文大小：831K
• 年卷期：v.116,no.9(March 8, 2012)
• ISSN：1932-7455

文摘

Biodegradable and biocompatible poly(p-dioxanone)鈥損oly(tetramethylene oxide)glycol (PPDO鈥揚TMEG) multiblock copolymers with excellent shape memory effect and mechanical properties were developed by coupling PPDO-diol and PTMEG-diol with 1,6-hexamethylene diisocyanate (HDI). The influences of chain structure, microphase separating morphology on shape memory effect, and biocompatibility were investigated systematically. The TEM observation of PPDO鈥揚TMEG poly(ether-ester)-polyether exhibited the relationship between characteristic microphase separating morphology and shape memory effect. Interestingly, differential scanning calorimetry (DSC) analysis indicated that T_g,PPDO was close to T_c,PTMEG, which provided the possibility that the reversible phase combined PTMEG segments and the amorphous phase of PPDO segments. The synergistic effect ensured copolymers owning both high R_f and R_r (96.6% and 92.9% with PTMEG segments only 15% in weight fraction), as well as the mechanical properties when T > T_trans. Moreover, biocompatible evaluation results showed that the cell adhesion and proliferation could be enhanced on copolymers with more PTMEG segments, indicating potential application in minimally invasive surgery.