Dammarane Triterpenes as Potential SIRT1 Activators from the Leaves of Panax ginseng

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• 作者：Jun-Li Yang ; Thi-Kim-Quy Ha ; Basanta Dhodary ; Kuk-Hwa Kim ; Junsoo Park ; Chul-Ho Lee ; Young-Choong Kim ; Won-Keun Oh
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：July 25, 2014
• 年：2014
• 卷：77
• 期：7
• 页码：1615-1623
• 全文大小：375K
• ISSN：1520-6025

文摘

During a search for SIRT1 activators originating in nature, three new dammarane triterpenes, 6伪,20(S)-dihydroxydammar-3,12-dione-24-ene (1), 6伪,20(S),24(S)-trihydroxydammar-3,12-dione-25-ene (2), and 6伪,20(S),25-trihydroxydammar-3,12-dione-23-ene (3), as well as two known triterpenes, dammar-20(22),24-diene-3尾,6伪,12尾-triol (4) and 20(S)-ginsenoside Rg₃ (5), were isolated from Panax ginseng leaves. Compounds 1 and 3鈥?b>5 showed potential as SIRT1 activators, as analyzed by in vitro enzyme-based SIRT1-NAD/NADH and SIRT1-p53 luciferase cell-based assays. They were also found to increase the level of NAD⁺/NADH ratio in HEK293 cells. This study presents a new class of chemical entities that may be able to be developed as SIRT1 activators for antiaging and treatment of age-associated diseases.