Isogarcinol Extracted from Garcinia mangostana L. Ameliorates Systemic Lupus Erythematosus-like Disease in a Murine Model

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• 作者：Wei Li ; Hu Li ; Mu Zhang ; Youxiu Zhong ; Mengqi Wang ; Juren Cen ; Hezhen Wu ; Yanfang Yang ; Qun Wei
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2015
• 出版时间：September 30, 2015
• 年：2015
• 卷：63
• 期：38
• 页码：8452-8459
• 全文大小：430K
• ISSN：1520-5118

文摘

Isogarcinol is a new immunosuppressant that we extracted from Garcinia mangostana L. In the present study, we elucidate its beneficial effect in chronic graft-versus-host disease (cGVHD) in mice -- a model for systemic lupus erythematosus (SLE) in human. The oral administration of 60 mg/kg isogarcinol significantly reduced proteinuria, corrected the abnormal serum biochemical indicator, and decreased the amount of serum antibodies and lowered the renal histopathology score. In addition, isogarcinol alleviated the abnormal activation of CD4 T cells and decreased the expression of inflammatory genes and cytokines in the kidneys and peritoneal macrophages. The mechanism of action of isogarcinol is associated with downregulation of CD4 T cells and inflammatory effects. Therefore, we believe that isogarcinol may be a potential therapeutic drug candidate for future treatment of SLE.