Carbocupration of 1-Alkynylphosphines Followed by Trapping with Electrophiles

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• 作者：Shigenari Kanemura ; Azusa Kondoh ; Hideki Yorimitsu ; Koichiro Oshima
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：May 10, 2007
• 年：2007
• 卷：9
• 期：10
• 页码：2031 - 2033
• 全文大小：78K
• 年卷期：v.9,no.10(May 10, 2007)
• ISSN：1523-7052

文摘

Treatment of 1-alkynylphosphine with magnesium dialkylcuprate in ether results in regio- and stereoselective syn-carbocupration. Thealkenylcopper intermediate reacts with electrophile, which leads to allylation, acylation, and phosphination. The phosphination offers a newroute to gem-diphosphinoalkene, an interesting phosphorus-based organic structure.