Photoredox-Catalyzed Hydroxymethylation of Heteroaromatic Bases

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• 作者：Chelsea A. Huff ; Ryan D. Cohen ; Kevin D. Dykstra ; Eric Streckfuss ; Daniel A. DiRocco ; Shane W. Krska
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：August 19, 2016
• 年：2016
• 卷：81
• 期：16
• 页码：6980-6987
• 全文大小：477K
• 年卷期：0
• ISSN：1520-6904

文摘

We report the development of a method for room-temperature C–H hydroxymethylation of heteroarenes. A key enabling advance in this work was achieved by implementing visible light photoredox catalysis that proved to be applicable to many classes of heteroarenes and tolerant of diverse functional groups found in druglike molecules.