Cu-Catalyzed Oxidative C(sp2)鈥揌 Cycloetherification of o-Arylphenols for the Preparation of Dibenzofurans

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• 作者：Jiaji Zhao ; Yong Wang ; Yimiao He ; Lanying Liu ; Qiang Zhu
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：February 17, 2012
• 年：2012
• 卷：14
• 期：4
• 页码：1078-1081
• 全文大小：763K
• 年卷期：v.14,no.4(February 17, 2012)
• ISSN：1523-7052

文摘

A new process involving copper-catalyzed aerobic C(sp²)鈥揌 activation, followed by cycloetherification, has been developed. This reaction serves as a direct method for the preparation of multisubstituted dibenzofurans starting with o-arylphenols. The presence of a strong para-electron-withdrawing group (e.g., NO₂) on the phenol is essential for the success of the reaction.