DNA Sequential Logic Gate Using Two-Ring DNA

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• 作者：Cheng Zhang ; Linjing Shen ; Chao Liang ; Yafei Dong ; Jing Yang ; Jin Xu
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：April 13, 2016
• 年：2016
• 卷：8
• 期：14
• 页码：9370-9376
• 全文大小：472K
• 年卷期：0
• ISSN：1944-8252

文摘

Sequential DNA detection is a fundamental issue for elucidating the interactive relationships among complex gene systems. Here, a sequential logic DNA gate was achieved by utilizing the two-ring DNA structure, with the ability to recognize “before” and “after” triggering sequences of DNA signals. By taking advantage of a “loop-open” mechanism, separations of two-ring DNAs were controlled. Three triggering pathways with different sequential DNA treatments were distinguished by comparing fluorescent outputs. Programmed nanoparticle arrangement guided by “interlocked” two-ring DNA was also constructed to demonstrate the achievement of designed nanostrucutres. Such sequential logic DNA operation may guide future molecular sensors to monitor more complex gene network in biological systems.