Janus Nanocage toward Platelet Delivery

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• 作者：Lin Tang ; Saina Yang ; Fuxin Liang ; Qian Wang ; Xiaozhong Qu ; Zhenzhong Yang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：May 18, 2016
• 年：2016
• 卷：8
• 期：19
• 页码：12056-12062
• 全文大小：533K
• 年卷期：0
• ISSN：1944-8252

文摘

The platelet-shaped Janus nanocages with a mesoporous silica shell are prepared. PEG moiety onto the exterior surface is responsible for good dispersity in water. The graphene sheet inside the cavity is responsible for hydrophobic performance to selectively capture hydrophobic species, and photothermal effect by NIR irradiation. As a biocompatible DOX-loaded Janus platelet delivery, HeLa cell cytotoxicity is greatly enhanced under NIR irradiation. There exists a synergetic effect between the chemotherapy and photothermal therapy.