Near-Infrared (NIR)-Absorbing Conjugated Polymer Dots as Highly Effective Photothermal Materials for In Vivo Cancer Therapy

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• 作者：Shengliang Li ; Xiaoyu Wang ; Rong Hu ; Hui Chen ; Meng Li ; Jianwu Wang ; Yunxia Wang ; Libing Liu ; Fengting Lv ; Xing-Jie Liang ; Shu Wang
• 刊名：Chemistry of Materials
• 出版年：2016
• 出版时间：December 13, 2016
• 年：2016
• 卷：28
• 期：23
• 页码：8669-8675
• 全文大小：542K
• ISSN：1520-5002

文摘

Photothermal therapy (PTT) holds great promise for noninvasive cancer treatment. To fulfill this goal, highly effective and low-risk photothermal agents have been intensively explored. Here, we present a new PTT material based on conjugated polymer dots (Pdots) that exhibit strong near-infrared (NIR) absorption and high photostability. The Pdots result in a thermal response upon illumination with a NIR laser, leading to a high photothermal conversion efficiency of 65%. Thus, the photothermal ablation of cancer cells using the Pdots both in vitro and in vivo can be achieved, highlighting the potential of Pdots as a nanoplatform for clinical therapy. They also open up a new avenue to develop new photothermal therapeutic materials.