Gadolinium Oxide Ultranarrow Nanorods as Multimodal Contrast Agents for Optical and Magnetic Resonance Imaging

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• 作者：Gautom Kumar Das ; Boon Chin Heng ; Sui-Choon Ng ; Tim White ; Joachim Say Chye Loo ; Loyola D’ ; Silva ; Parasuraman Padmanabhan ; Kishore K. Bhakoo ; Subramanian Tamil Selvan ; Timothy Thatt Yang Tan
• 刊名：Langmuir
• 出版年：2010
• 出版时间：June 1, 2010
• 年：2010
• 卷：26
• 期：11
• 页码：8959-8965
• 全文大小：934K
• 年卷期：v.26,no.11(June 1, 2010)
• ISSN：1520-5827

文摘

We demonstrate a simple synthetic strategy for the fabrication of single-phase rare earth (RE) doped gadolinium oxide (Gd₂O₃:RE where RE = terbium (Tb), ytterbium (Yb), and erbium (Er)) nanorods (NRs) as multimodal imaging probes. The NRs are ultranarrow and exhibit both emission and magnetic characteristics. The Tb-doped and Yb/Er-codoped Gd₂O₃ NRs exhibit down- and up-conversion fluorescence respectively, and also exhibit paramagnetism. Importantly, these codoped NRs possess excellent magnetic characteristics, as shown in their longitudinal relaxation time (T1) -weighted image contrast, which is closer to that of commercial Gadovist for magnetic resonance imaging (MRI) applications. This property opens up new avenues in the development of contrast agents.