Screening of plants from New Caledonia for antiplasmodial activity against
Plasmodium falciparumrevealed that methanolic extracts of the leaves and bark of
Tristaniopsis calobuxus,
T. yateensis, and
T.glauca inhibited the growth of chloroquine-sensitive and -resistant clones. Ellagic acid and the newcompound 3,4,5-trimethoxyphenyl-(6'-
O-galloyl)-
O-
-
D-glucopyranoside were identified as the activeconstituents (IC
50 0.5 and 3.2
M, respectively). The growth inhibition of both clones was comparable.The compounds showed negligible or very low cytotoxicity to human skin fibroblasts and Hep G2 cellswhen tested at concentrations ranging from 0.5 to 100
M.