19-epi-Okadaic Acid, a Novel Protein Phosphatase Inhibitor with Enhanced Selectivity

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• 作者：Patricia G. Cruz ; Antonio Hern&aacute ; ndez Daranas ; José ; J. Fern&aacute ; ndez ; Manuel Norte
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：August 2, 2007
• 年：2007
• 卷：9
• 期：16
• 页码：3045 - 3048
• 全文大小：139K
• 年卷期：v.9,no.16(August 2, 2007)
• ISSN：1523-7052

文摘

A new protein phosphatase inhibitor, 19-epi-okadaic acid, was isolated from the marine dinoflagellate Prorocentrum belizeanum. Its structureand conformation in solution has been determined, and important differences were found when compared with the lead compound okadaicacid. The new metabolite showed nanomolar activities, and its selectivity for PP2A versus PP1 surpasses that shown by okadaic acid 10-fold,making it one of the most selective inhibitors of this class.