Synthesis of Pyridines from Ketoximes and Terminal Alkynes via C鈥揌 Bond Functionalization

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• 作者：Rhia M. Martin ; Robert G. Bergman ; Jonathan A. Ellman
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：March 2, 2012
• 年：2012
• 卷：77
• 期：5
• 页码：2501-2507
• 全文大小：310K
• 年卷期：v.77,no.5(March 2, 2012)
• ISSN：1520-6904

文摘

An expedient one-pot rhodium catalyzed C鈥揌 bond functionalization/electrocyclization/dehydration procedure has been developed for the synthesis of highly substituted pyridine derivatives from terminal alkynes and 伪,尾-unsaturated ketoximes. The use of electron-deficient phosphite ligands is important to suppress dimerization of the terminal alkynes to enynes.