Niizalactams A–C, Multicyclic Macrolactams Isolated from Combined Culture of Streptomyces with Mycolic Acid-Containing Bacterium

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• 作者：Shotaro Hoshino ; Masahiro Okada ; Toshiyuki Wakimoto ; Huiping Zhang ; Fumiaki Hayashi ; Hiroyasu Onaka ; Ikuro Abe
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：December 24, 2015
• 年：2015
• 卷：78
• 期：12
• 页码：3011-3017
• 全文大小：391K
• ISSN：1520-6025

文摘

A terrestrial bacterium, Streptomyces sp. NZ-6, produced niizalactams A–C (1–3), unprecedented di- and tricyclic macrolactams, by coculturing with the mycolic acid-containing bacterium Tsukamurella pulmonis TP-B0596. Their complete structures, including absolute configurations, were elucidated on the basis of spectroscopic data and chemical derivatization. Their unique skeletons are proposed to be biosynthesized from a common 26-membered macrolactam intermediate by S_N2 cyclization or an intramolecular Diels–Alder reaction.