Pd(II)-Catalyzed Olefination of sp3 C−H Bonds

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• 作者：Masayuki Wasa ; Keary M. Engle ; Jin-Quan Yu
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：March 24, 2010
• 年：2010
• 卷：132
• 期：11
• 页码：3680-3681
• 全文大小：166K
• 年卷期：v.132,no.11(March 24, 2010)
• ISSN：1520-5126

文摘

The first Pd(II)-catalyzed sp³ C−H olefination reaction has been developed using N-arylamide directing groups. Following olefination, the resulting intermediates were found to undergo rapid 1,4-addition to give the corresponding γ-lactams. Notably, this method was effective with substrates containing α-hydrogen atoms and could be applied to effect methylene C−H olefination of cyclopropane substrates.