Targeted Molecular Imaging of Cancer Cells Using MS2-Based 129Xe NMR

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• 作者：Keunhong Jeong ; Chawita Netirojjanakul ; Henrik K. Munch ; Jinny Sun ; Joel A. Finbloom ; David E. Wemmer ; Alexander Pines ; Matthew B. Francis
• 刊名：Bioconjugate Chemistry
• 出版年：2016
• 出版时间：August 17, 2016
• 年：2016
• 卷：27
• 期：8
• 页码：1796-1801
• 全文大小：358K
• 年卷期：0
• ISSN：1520-4812

文摘

We have synthesized targeted, selective, and highly sensitive ¹²⁹Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized ¹²⁹Xe NMR signal contrast and hyper-CEST ¹²⁹Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized ¹²⁹Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.