Cobalt-Catalyzed Diastereoselective Synthesis of C-Furanosides. Total Synthesis of (鈭?-Isoaltholactone

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• 作者：Lionel Nicolas ; Eva Izquierdo ; Patrick Angibaud ; Ian Stansfield ; Lieven Meerpoel ; S茅bastien Reymond ; Janine Cossy
• 刊名：Journal of Organic Chemistry
• 出版年：2013
• 出版时间：December 6, 2013
• 年：2013
• 卷：78
• 期：23
• 页码：11807-11814
• 全文大小：339K
• 年卷期：v.78,no.23(December 6, 2013)
• ISSN：1520-6904

文摘

An array of C-aryl and C-vinyl furanosides were prepared in good yields and diastereoselectivities from C-halogeno furanosides either with aryl Grignard or with vinyl Grignard using the convenient Co(acac)₃/TMEDA catalytic system. This method is illustrated by the total synthesis of the (鈭?-isoaltholactone.